If I can help someone, fine. If people do not wish to find out all they can about their disease that is fine too. Lung cancer survivors support group and discussion community, http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-lung-cancers?utm_source=www.GreenMedInfo.com&utm_campaign=2189ddd3c1-Greenmedinfo&utm_medium=email&utm_term=0_193c8492fb-2189ddd3c1-87046221. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. However, the study looked at the incrase of ALL lung cancers, not SCLC, so that data does not correlate with this study. It looks at correlations, as if they had any merit on their own. Thyroid dysfunction after immune checkpoint inhibitor treatment in a single-center Chinese cohort: a retrospective study An Italian study published in the journalReproductive Biology and Endocrinology,titled Levothyroxine and lung cancer in females: the importance of oxidative stress, has raised a concerning possibility: levothyroxine (T4), one of the worlds most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. millions treated for hypothyroidism at risk for lung cancer I very much appreciate the information you shared. But I for one, do appreciate anything that other members forward about potential links, causes, aids to healing, whatever you can them. Millions of people who were not only wrongly diagnosed with 'cancers' and subsequently aggressively treated for them with chemotherapy, radiation and surgery, are now being told that they would have been better left undiagnosed and untreated. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. The estimated 2.3 million new cases indicate that 1 in every 8 cancers diagnosed in . But what can be done for patients who are at low It does not necessarily imply one thing caused the other. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic 'self-fulfilling prophecy' if you will. Methods: The study group included 35 patients (15 women, 20 men, 65.8 7.1 years) with NSCLC in stage IIIB (n = 16, 45.7%) and IV (n = 19,54.3%) who were treated with nivolumab. El almacenamiento o acceso tcnico que es utilizado exclusivamente con fines estadsticos. Monaldi Arch Chest Dis 2003, 59:140145. Untreated hypothyroidism increases morbidity and mortality. Marketed as superior to traditional glandular forms extracted from pigs (whose endocrine glands are far more bioidentical than any other animal we know of) due to the dose-to-dose standardization of the so-called 'active ingredient' T4 versus the natural variations in hormone concentrations found in the 'real thing,' which incidentally contains a wide range of additional hormones including T1, T2, T3, all of which are vitally important. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. Those with the greatest risk of developing thyroid disorders are women who have a family history of the disease. Ultimately, this latest Italian study is bringing to our attention one of what is likely a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. [3] Faber J, Poulsen S, Iversen P, Kirkegaard C: Thyroid hormone turnover in patients with small cell carcinoma of the lung. Cancer-related Fatigue in Lung Cancer: A Research Agenda: An Official I have posted the link, so you can see if it has any merit. I do not believe in random events, of nature or otherwise. The increasingly global medical-industrial complex has begun to co-opt all aspects of the natural human bodily life cycle, and all the organ systems within it, as potential targets of medical surveillance and intervention, not excluding the human thyroid. Thank you for bringing it to our attention. Risk of cancer in long-term levothyroxine users: Retrospective - PubMed Due to excessive bot signups along with nefarious actors we are limiting forum registration. If You Don't Want Older Bones, Don't Be Low In Vit Background Mortality Rate for Vaccines, or Pseudo Everything You Ever Wanted to Know About Black Seeds. It may not display this or other websites correctly. is the fiec part of the evangelical alliance; townhomes in avalon park; 8 ft windmill parts; why is my cash and sweep vehicle negative; nordstrom rack return policy worn shoes Also this study finds no link with breast cancer, when others have found a link. Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. [4] Ratcliffe JG, Stack BH, Burt RW, Radcliffe WA, Spilg WG, Cuthbert J, Kennedy RS: Thyroid function in lung cancer. She wrote about a product called Thyrtophin PMG. Even in the mildest form, hypothyroidism affects the heart. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer There is evidence T4 makes cancer more agressive, so although it increases the risk of cancer the mortality risk is higher. [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. and our Forgot account? Capmatinib (Tabrecta) is the first FDA-approved MET-targeting medication for treating metastatic NSCLC. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer I don't believe there are thousands of people on to high a dose of t4, so why does it feel they are hyper? There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight. International Journal of Human Nutrition and Functional Medicine, Black Seed May Treat Hypothyroidism (Hashimotos Disease), Clinical Trial Reveals, Wi-Fi Devices Increase Mercury Release From Dental Amalgams, Participating in Drum Circles Improves Health and Quality of Life in Parkinsons Patients (Study), Acupuncture Beats Injected Morphine for Pain: Groundbreaking Study, Mammography Is Harmful and Should Be Abandoned, Scientific Review Concludes, Killer Germs Obliterated by Medicinal Smoke Smudging, Study Reveals, Turmerics Smart Kill Properties Put Chemo & Radiation To Shame, Beet Juice Boosts Cognitive Function In One Dose, 13 Evidence-Based Medicinal Properties of Coconut Oil, Group Drumming Better Than Prozac, Study Suggests, 25 Cancer Stem-Cell Killing Foods That Are Smarter Than Chemo and Radiation, Ibuprofen Can Stop Your Heart 31% Increase in Cardiac Arrest Risk, Conscious Shopping Offering Conscious Products for Conscious People, Uncovering The Truths And Myths About 3 Superstar Herbs, Living Past 100: The Okinawan Diet and Blue Zone Centenarians, Repairs DNA and Rejuvenates Your Cells While You Relax, Why Daily Greens are the Real Fountain of Youth, T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. Are you sure you want to block this member? In fact, it is the high levels of T4 that make them more susceptible to cancer. Yes, lung cancer patients can have these symptoms, but so do patients who have other cancers. This discussion has been closed to comments. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional. Currently, the best practical approach is to base treatment decisions on the degree of TSH elevation, thyroid autoimmunity, and associated comorbidities. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related diseases.. This article is copyrighted by GreenMedInfo LLC, 2013, Some features are currently member only features. They only reappear when I need to fine tune the medication. END TIME NEWS, A CALL FOR REPENTANCE, YESHUA THE ONLY WAY TO HEAVEN. PMID 11836274. Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. I have so many women friends and family members who have recently been diagnosed with hypothyroidism and their doctors put them all on Synthyroid. The authors of the study pointed out that levothyroxine (T4) treatment can lead to medication-induced (iatrogenic) thyroid over-activity (hyperthyroidism) and oxidative stress that can lead to a significant patient discomfort. Savvy Senior: Could you have a thyroid problem and not even know it? Also, what is oxidised stress??? 16.6k members in the AlternativeHealth community. Factors found to be associated with mortality were age, senile dementia, congestive heart failure, chronic renal failure, and a history of cerebrovascular disease. The Goji Berry: The Jolly Super Food That Gives Yo How to Prevent and Treat Insect Bites Without Hars Supreme Court Rules Drug Companies Exempt From Law Spain Study Confirms Hemp Oil Cures Cancer without Wheatgrass Turns Gray Hair Back to Its Natural Color, Medicinal Cannabis Used To Prevent Cancer Growth. PLoSone 2011, 11:e27547. PMID: 11929079, [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. I cried with joy when I found out there was something really wrong with me. Privacy Policy. Respiratory function in thyroid disease - UpToDate I have always found this condition a riddle. You may not notice signs or symptoms of the disease. Endocrinology 2008, 149:22412250. In 2011 I switched docs and was put on Armour as he told me Synthroid and the like are poison and they do not work. Why not simply call it selenium deficiency? Angiology 2000, 51:S65S68. [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Posted on: Monday, August 12th 2013 at 7:15 am Written By: Sayer Ji, Founder A new study has. Respiratory system Hypothyroidism weakens the respiratory muscles and decreases lung function. [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. Overtreatment, of course, is the hallmark danger of overdiagnosis. View the data on GreenMedInfos Hypothyroidism Research page. Another recently approved drug is tepotinib (Tepmetko). Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). I read somewhere about the work done many years ago which was mistakenly read and accepted 28 y/o F Low levels across the board for TSH, T3, and T4, Acid reflux drug linked to more than doubled risk of stomach cancer study, thyroiduk.org - further-reading - thyroid-diagnosis-and-treatment. Is Drug-Based Medicine a Form of Human Sacrifice? [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. Very interesting article, thank you for sharing. [3], An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5-monodeiodination (DI). florence nightingale concept 2 via de boleto The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. I was sure that the paper had been discussed here shortly after publication in 2013, but cannot find the thread! J Exp Biol 2010, 213:28992911. Keri Topouzian, D.O. Physician/Author - Facebook Risk of cancer in longterm levothyroxine users: Retrospective May be of interest: Study: Millions Treated for Hypothyroidism At Risk for, Non-small cell lung cancer - Adenocarcinoma, Non-small cell lung cancer - Squamous cell, Top 5 Questions to Ask Your Lung Cancer Doctor, Patient & Caregiver Network Member Resources, Not A Member Yet? The Flu Propaganda Matrix Continues To Promote Fea B Vitamins Slow Alzheimer's and Grey Matter Loss. The relationship between levothyroxine use and cancer risk is largely underdetermined. I'm just saying the evidence presented in this article isn't very strong, and more study is needed to show Synthroid causes lung cancer. Angiology 2000, 51:S65S68. video where the doc is talking about the study , i wlll link study and video below. A total of 425 inpatients with malignant tumors were treated with ICIs at PUMCH during the study period. PMID: 23539727, [16] Alan R Gaby. I think part of sharing information here on Inspire is the discussions about the articles we share. [3], An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5'-monodeiodination (DI). Finally, they pointed out that T4, which is a synthetic form of thyroid hormone, might be avoided if T3 or the desiccated pig-derived form known as Armour Thyroid was used to control the oxidative-stress producing hydroperoxides. elevated TSH, without actually improving the overall physiological situation, nor the patients subjective experience of well being. In 2020 alone, there were more than 2.2 million new cases and 1.8 million deaths from lung cancer globally. When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Here members can share stories, find important information and learn from the experiences of others like themselves. El almacenamiento o acceso tcnico que se utiliza exclusivamente con fines estadsticos annimos. Targeted therapy for lung cancer: Side effects and more In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. This relatively symptom-free reservoir of hypothyroid cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. Study: Millions Treated for Hypothyroidism At Risk of Lung Cancer. Tokushima J Exp Med 1991, 38:2535. Study: Millions Treated for Hypothyroidism at Risk of Lung Cancer Intuition and Trust: a Personal Journey Through Ancient Pathways, Meditation, Yoga, Grounding & Mindfulness, Levothyroxine and lung cancer in females: the importance of oxidative stress, 2013 announcement by a National Cancer Institute, T-score based definition of osteoporosis and osteopenia, 30-billion dollar a year market in statin drugs, Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III).