There are two ways Ive discovered that I may be able to save the world, he told an IEEE Spectrum reporter in 2000. JAMA Reports Fluvoxamine as Potential Early Treatment for COVID-19 Andrew Wakefield after 25 years: Paving the way for COVID-19 quacks and The reason that it isnt used is because the medical community ignores evidence-based medicine principles. It has shown to be 100% protective of hospitalization in 2 clinical trials. NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). The data we have today with just 2 clinical trials (RCT and confirmatory RWE) is compelling. vocus . Links to evidence about fluvoxamine including the public data repository. Read More fluvoxamine The Fluvoxamine FAQ Late in the session, minutes before this impromptu video wrap up, Tip o' Spear Steve Kirsch addressed the panel and revealed that the FDA had just shot down Fluvoxamine as an approved COVID treatment. So you can address your OCD and if you get COVID, youll can up the dose. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. Or just depression about the vaccine mandates? But an Editor's Note urged physicians to treat this as a hypothesis and not as a basis for clinical decision-making. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. Some speaker, off camera, went on a . After one or two conversations like that, I got tired of arguing, so I started avoiding his calls.. How can we get fluvoxamine? Several other trials around the world are in the final stages, too. The data is there in plain sight for anyone to see today. Here's why. You can help by bringing this document to your doctor's attention. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! The premise made sense: Most experts were predicting vaccines would take years, while finding helpful drugs with known safety profiles could shortcut the approval process. Fluvoxamine Data Unveiled as Promising Early Treatment in Patients with Fluvoxamine public data repository: The fluvoxamine public repository has all the documents related to fluvoxamine for COVID, including the RCT, RWE, observational studies and a link to the 1 hour lecture on serotonin and fluvoxamine. Dosage there is 30mg once a day. It was not compatible with his position as CEO to continue taking a very public stance on the vaccines, Richard Char, M10s general counsel, told me. The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. CETF founder Steve Kirsch accepted an invitation to discuss the findings on a weekly . The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). Although there is evidence that fluvoxamine can prevent clinical worsening and the need for hospitalizations in outpatients with early covid-19, I have seen no good evidence that fluvoxamine is useful as a substitute for the vaccines, co-investigator Angela Reiersen wrote to me. I took it myself at that dosage and noticed zero side effects. Its not about the science. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. I didnt intend to spend a lot of time on Steve in particular, but that video was so influential.. He is very smart, and he knows that he is very smart, and hesometimes he behaves like he thinks hes the smartest guy in the room, whether he is or isnt, he told me. To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. After several failed attempts to stop the progression of his disease, he designed his own protocol for chemotherapy and doctor-shopped to find an oncologist who would give it to him. People are dying because of physician fear of a new treatment with a 100% success rate and a solid mechanism of action. PDF How I would treat COVID - Steve Kirsch It should be crystal clear to everyone that the current CDC guidelines for treating COVID aren't working. Press - treatearly.org Patients should be advised to limit/avoid the use of caffeine while on the drug since fluvoxamine extends the half life of caffeine (making you super wired). Steve Kirsch cut the check, which allowed Dr. Lenze to finish recruiting the 152 patients he needed for his trial. Steve Kirsch (@stkirsch) / Twitter - Twitter. It's what's happening February 17, 2021. . Personal life. Incriminating evidence - Steve Kirsch's newsletter - Substack That work has yielded one promising candidate, the antidepressant fluvoxamine; other CETF-funded efforts have been less successful. reach out to us at Proven in clinical use all over the world. Hes a genuinely good guy. Steve angrily decried this development as more evidence of FDA corruption. Its actually much harder to parse out a signal than if youre treating diabetes or cancer., In addition to the issues with fluvoxamine, advisors grew increasingly uncomfortable with Kirschs posts about ivermectin, which he has repeatedly claimed in blog posts and appearances in alternative media can be used together with fluvoxamine to prevent 100% of covid-19 deaths. Fluvoxamine, created 37 years ago, is an inexpensive and widely available generic drug. On January 22, 2021, thirty key opinion leaders (KOL) from NIH, CDC, and leading academic institutions met to review the evidence for using fluvoxamine for treating COVID. At that dose, no side effects were reported for his patients (I know of only one person who had mild nausea at that dose) and everyone reversed out their symptoms in an average of 3 days. . . (The ivermectin data are trash, Feinberg told me. In short, a lot of mumbo jumbo. He considers himself an expert in something that he doesnt have training or experience in, and hes not following scientific methods to assess data.. When was the last time you saw a phase 3 fail where there was a 100% effect size in both an RCT and RWE study along with 4 independent observational trials all showing a positive effect, and there is clear mechanism of action where there is less than a 1% chance that it is not working (the SSRI's ordered their impact based on their Sigma activation which is 1 in 120 options), and where in every single case we are aware of the patient taking the drug reversed to normal in an average of 3 days? People who report not tolerating the drug are typically prescribed too high a dose. The Wall Street Journal thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). This is the gold standard of evidence based medicine, Article about the fluvoxamine rejection (The Verge). Be warned!. (One of them, Eric Lenze, was in fact giving a presentation on fluvoxamine to the National Institutes of Health the next day.) An approach that promised to democratize design may have done the opposite. Download Citation | On Mar 1, 2023, Gne Seda Albayrak and others published A Cross-Sectional Study on the Personality Traits of Episodic and Chronic Migraine Patients | Find, read and cite all . Some people report mild nausea while on the drug (stops when stop the drug). As a health care journalist, I started off firmly in the wait-and-see camp on mRNA vaccines. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. Completely avoid caffeine, alcohol, tylenol, and benadryl. So when a group of scientists applied for an EUA for fluvoxamine, what did the FDA do? Compulsive hand washing? This advice is now outdated. I also think it makes a lot of sense to look for pre-existing drugs that can help treat covid symptoms. Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. This was shown to be very tolerable (no side effects in 99% of patients) and extremely effective (no hospitalizations and death if you start it ASAP after first symptoms). Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. The medical community doesnt care about saving lives. The drug was widely prescribed as a covid treatment for much of 2020, based on anecdotes and flawed studies. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. My crime? Steve Kirsch. Kirsch, though, often relies on the heartstrings to smooth over a lack of data. Skirsch.io traffic volume is 1,957 unique daily visitors and their 3,914 pageviews. Medium banned him for misinformation. A Cross-Sectional Study on the Personality Traits of Episodic and No long haul symptoms if you start the drug ASAP after first symptoms. If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. May 16, 2022. Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. Fluvoxamine was reportedly added to just 2 practice guidelines (Ontario and Johns Hopkins). Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. All the medical journals refused to publish the meeting notes (rejected by 6 journals). The case for fluvoxamine for treating COVID-19 - Steve Kirsch Home page Still, in the moment, his question threw me, and I stuttered. . Instead, the government prefers to fund and promote new, proprietary drugs and vaccines, he says. I couldn't agree more. Fluvoxamine has a 40 year safety track record. Steve Kirsch is baffled. Thanks for working tirelessly to help others. Online Status. This was shown to be very tolerable (no side effects in 99% of patients) and extremely effective (no hospitalizations and death if you start it ASAP after first symptoms). Food/drugs to avoid while on fluvoxamine. In 2016, it was the 135th most-prescribed medication in the United States, with more than 4 million prescriptions. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. The effect size is huge if the drug is given early right after symptoms start. He started a covid-19 vaccine company. fluvoxamine The fast, easy, safe, simple, low cost treatment for COVID that has worked 100% of the time to prevent hospitalization that nobody wants to talk about We now have a viable solution to reduce COVID hospitalization and mortality; Read More fluvoxamine Got COVID? Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. I asked to give a talk about COVID at MIT, but they couldn't find a faculty member to sponsor it. 'In every single case, treat virus early and treat it hard': Steve Kirsch Why not fluvoxamine? CETF was founded by entrepreneur and philanthropist Steve Kirsch, as a way to expedite the fight against COVID-19. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Steve Kirsch - COVID-19 Early Treatment Fund He is the inventor of the optical mouse and one of the first Internet search engines, Infoseek. It's hard to ignore this lecture in explaining why the drug is so effective. Server IP cope with resolved: Yes Http reaction code: 200 Response time: 0.27 sec. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. If you cant lay off the java, then try fluoxetine (Prozac). In-patient use. Its board told him that if he wanted to remain part of the company he would have to stop making public anti-vaccine statements. This suggests that a 50mg BID loading dose for day one, followed by 50mg QD dose for the following 13 days should also be quite effective. Elsewhere he has said he began questioning vaccine safety after an unnamed Twitter follower told him several family members died after getting their shots. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. No long haul symptoms if you start the drug ASAP after first symptoms. If you start later, doctors use higher dosages and compliance becomes a bigger problem. He is frequently brash and interruptive, peppering dire warnings about vaccines with veiled aspersions toward Anthony Fauci and vague references to influential people who agree with him in private but cannot speak publicly. Proxalutamide and fluvoxamine pushers and the early treatment grift. and increased heart rate (which could be nerves about the dilated pupils). Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. In that same IEEE Spectrum story about his then-new startup, Propel Software, he said he felt successful, but not famous. As noted before, the repository has a link to the 1 hour serotonin lecture. The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. By Steve Kirsch in fluvoxamine Feb 14, 2021 The case for fluvoxamine for treating COVID-19 A very short op-ed arguing for using fluvoxamine against COVID. Avoid caffeine, benadryl, tylenol, and alcohol. 21. Im just telling you the truth. Long haul. He said of his study, This is the most extraordinary effect Ive seen in my 25 years practicing medicine.. The FDA approved Molnupiravir which was less effective. Physicians who use the drug for COVID now swear by it. Some countries dont have fluvoxamine so this is the alternative. This give another 50% of benefit. The collateral damage is that, now, a lot of people dont trust scientific leaders or the scientific community. This 1/6 of the dose the FDA has approved for OCD (the labelled indication for fluvoxamine)! No one has been able to come up with an example where phase 2 + this level of evidence resulted in a failure of Phase 3. Boulware disputes that, and says that although Kirschs funding was important, his statements about drugs and vaccines have proven problematic. In two trials (both published studies in peer reviewed journals with Editor's Choice in both cases), the drug had a 100% effect size in protecting against hospitalization from the respiratory symptoms from COVID. Its all about NIH saying it is OK. . Steve put in $1MM of his own money and . P-value was 10^-14 on that study (done by Dr. Seftel). Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel, this is NOT about the science. One Silicon Valley entrepreneur thought he could beat the odds. The paramedics will think you are on drugs. But how many did it help? Los Altos Hills resident Steve Kirsch funded research into the drug fluvoxamine as a treatment for COVID-19. The FDA is will take months to deliberate on the fluvoxamine EUA application that we submitted on January 29. There are other non-prescription things you should always have on hand. With little government funding available for such work, Kirsch founded the Covid-19 Early Treatment Fund (CETF), putting in $1 million of his own money and bringing in donations from Silicon Valley luminaries: the CETF website lists the foundations of Marc Benioff and Elon Musk as donors. As of January 18, 2021, the CDC estimates that 90,000 Americans will die from COVID in just the next 3 weeks. (The fund borrows its nonprofit status from the 501(c)(3) Rockefeller Philanthropy Advisors, which managed its money until it quit, according to the Daily Beast; neither organization is related to the Rockefeller Foundation, which supports Technology Review's reporting on covid.). Dosing. 22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. Compulsive hand washing? They all promised me when fluvoxamine passed Phase 3 trials, nearly everyone would use it. fluvoxamine - Steve Kirsch Home page Should I take ivermectin or fluvoxamine or both? - Quora 12:45 AM . Dr. Joe Ladapo wrote a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients." He has made millions from these projects, even if they have not turned him into a household name. I fully expected both organizations to do absolutely nothing. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. I learned this the hard way. That was a lie. Telling the truth, he tweeted. Steve Kirsch and the Seduction of Simplicity - McGill University One user reported dilated pupils and increased heart rate (which could be nerves about the dilated pupils). There are at least eight mechanisms of action that we think contribute to the effectiveness of this drug. You can use fluoxetine as well (aka Prozac). This is the gold standard of evidence based medicine. By Steve Kirsch Mar 14, 2021 Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for a single drug to be 100% successful. In it, he claimed mRNA vaccines kill one in 5,000 recipients and dramatically increase the rate of miscarriages. He immediately tweeted an offer to give anyone $1 million if they could win a debate with him about vaccine deaths. While he declined a phone interview, Boulware was recently the subject of a Mother Jones article about the harassment hes received for his research on hydroxychloroquine and ivermectin. Online Status. Also, this drug is only prescribed by psychiatrists so most doctors have no experience whatsoever with the drug. Here are the key things you should know about fluvoxamine for COVID: It works. Its all about NIH saying it is OK. Medicine today is driven by government opinion, not science. Is fluvoxamine helpful for patients with the coronavirus? Is it - Quora But as Kirsch has clashed with the experts he initially surrounded himself with, hes grown increasingly close to others who share his perspectives on vaccineswho have, in turn, provided a large and receptive audience to his claims about a fluvoxamine conspiracy. Adverse reactions/side effects. Fluvoxamine, Proxalutamide, and Ivermectin: 100% success Steve Kirsch: Don't Get the Vax! Early Treatment Saves Lives How the FDA justified rejecting an EUA for fluvoxamine All the researchers are convinced the drug works. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. But I know something else that few other people know, thanks to a source at the NIH: the NIH was planning to approve fluvoxamine months ago, but they got a call from the FDA telling them not to. . The sooner you start, the better the outcomes. He applied the drug to a large COVID outbreak at Golden Gate Fields just days after the Lenze trial was published. Saving the world has been a theme of Kirschs life for years. In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. He retired at the largest pension in federal history. I fully expected both organizations to do absolutely nothing. Theyre finding alternative leaders to follow, Morris said. Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. While YouTube has repeatedly taken down the full video of the DarkHorse episode, various clips have been watched over 4 million times, and the full audio remains available on Spotify. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Fluvoxamine: The evidence - Steve Kirsch Home page My website. Silence from the medical community. Three of the four outpatient trials have been reported out: all were successful. That way you can start immediately. I must admit that this is an anniversary that snuck The agency quickly slapped down the comments from Kirsch, a tech mogul with a fortune once estimated at $230 million, even as the claims triggered a flurry of false social-media posts attributing. In some cases, youd want to taper down the dosage. Summary of key evidence. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. In June, after CETFs advisory board resigned, Kirsch did a Facebook Live video with Zelenko and celebrity rehab coach Dr. Drew. Compulsive fiddling with your mask? That is when the phase 2 results were published. If you cant get a prescription for COVID, then perhaps you have OCD? Medicine isnt about saving lives anymore. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. Answer (1 of 2): Yes, In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious compli. There is an executive summary below, but the most important thing is that top infectious disease docs who have looked at all the evidence (including the two clinical trial results) believe the effect size is 75% or more in reducing the hospitalization rate. There is no evidence fluvoxamine is harmful and led to a worse outcome. A few months ago, Kirsch suddenly stopped promoting hydroxychloroquineeven scrubbing it from the CETFs official list of trials it has funded. So probability of successful Phase 3 can be estimated to be over 99.99% since there are tens of thousands of phase 3 studies. See my article on treatments. And he wont talk to you either if you ask nosy questions like Cliff, my risk benefit analysis shows you should be rushing to recommend this drug. While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. The claim that the spike is toxic, that came directly from the [DarkHorse episode]. sorry about that. Should you get vaccinated? Steve Kirsch | TrialSite News 707. Today, we are letting people drown and we are not even telling them there is a life preserver they can ask for today with compelling evidence that is under consideration by the life preserver safety group. The 5 observational studies is icing on the cake. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. About 10 minutes on the internet will show you those two gentlemen, who have appeared together, have been extensively fact checked for false or misleading claims or misuse of VAERS reporting and other data. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. The CDC has advised everyone to wear a mask. By Steve Kirsch Last updated: March 14, 2021 After I appeared on the60 Mi nut es story about fluvoxamine,I've received a lot of questions from people about how to treat COVID. I couldnt tell I was on the drug. The reason is pure corruption. The documents in the data room discuss all eight (you'll need access to the restricted area to see the presentation on all 8). 95% confidence effect size is 75% or more. Dosage there is 30mg once a day.